ncRNA name | MsrB1 siRNA |
ncRNA Category | siRNA |
Disease name | diabetic cataract |
Species | Homo sapiens |
Tissues/Cell_line | human lens epithelial cell line SRA01/04 |
Methods | siRNA transfection, MTT assay, qPCR, Western blot, flow cytometry, PI staining |
Expression pattern | associated |
Functional description | MsrB1 gene silencing by siRNA in HLE cells clearly resulted in oxidative stress, decrease in mitochondrial membrane potential and release of mitochondrial cytochrome c as well as an increase in activity of caspase-3 and the percentage of apoptotic cells. When MsrB1-silenced HLE cells were exposed to high glucose, characteristic of high-glucose-induced mitochondrial dysfunctions were further exacerbated. |
PubMed ID | 23270945 |
Year | 2013 |
Title | Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. |
Drug-related ncRNA | NO |
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